How to Measure Oxygen Saturation Using Pulse Oximeter: 15 Steps - wikiHow You can measure the blood's percentage of oxygen saturation using a pulse oximeter, a clip-like sensor device that is placed on a thin part of your body, such as an earlobe or nose. Part 1 Preparing to Use a Pulse Oximeter 1 Understand the relationship between oxygen and the blood. Oxygen is breathed into the lungs.